Systemic lupus erythematosus sle is a chronic multisystemic autoimmune disease with a highly heterogeneous pattern of clinical and serological manifestations. Additional oral manifestations of lupus erythematosus may include honeycomb plaques. We undertook a retrospective singlecentre study looking at oral findings in patients attending our multidisciplinary lupus clinic between. Erythema multiforme lupus erythematosus this is a chronic autoimmune disorder that has 2 main forms. Aug 15, 2016 systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. The types of skin lesions in each group are clinically distinct and recognizing the specific subsets helps in prognosticating the likelihood of underlying systemic lupus. There are some types of lupus that just affect the skin such as discoid lupus erythematosus and subacute cutaneous lupus erythematosus. It is more common in african americans and people of american indian and asian descent than in white people. The purpose of this pilot study was to assess the prevalence of oral manifestations among systemic lupus erythematosus sle patients in qatar, in order to warrant future studies that would investigate each one of these manifestations with detail and further scrutiny. Lupus erythematosus, an autoimmune disorder that causes chronic inflammation in various parts of the body. The disease can affect all ages but most commonly begins from 2045 years of age.
Additional oral manifestations of lupus erythematosus may. Three main types of lupus are recognizeddiscoid, druginduced, and systemic. The diagnosis of systemic lupus erythematosus requires the presence of four or. Keratoconjunctivitis sicca is the most common manifestation. Druginduced lupus, similar to sle, which is caused by an overreaction to certain medications. When internal organs are involved, the condition is referred to as systemic lupus erythematosus sle. Lupus is an autoimmune disease or a disease that starts because of an abnormal functioning of your immune system. Systemic lupus erythematosus sle or lupus medicinenet. Systemic lupus erythematosus in children and adolescents. Lupus shares a lot of symptoms with other diseases, like arthritis and diabetes. Mar 27, 2006 systemic lupus erythematosus sle is a clinically heterogeneous disease, which is autoimmune in origin and is characterized by the presence of autoantibodies directed against nuclear antigens.
Oral manifestations of systemic lupus erythematosus. The most common type of lupus is called systemic lupus erythematosus sle, which affects many parts of the body. In general, the clinical picture, causal microorganisms, and response to therapy are similar to that of hivnegative patients. Symptoms vary between people and may be mild to severe. Systemic lupus erythematosus orphanet journal of rare. The active periods, also called flares, are when you have.
Oral manifestations of lupus erythematosus report of two. In lupus, the bodys immune system, which normally functions to protect against foreign invaders, becomes. Clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate background. Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel.
Jun 19, 2015 systemic lupus erythematosus sle is an autoimmune disease with a prevalence of 36. Systemic lupus erythematosus sle is a chronic autoimmune disease that can involve any organ system with a wide range of disease manifestations, and can lead to significant morbidity and even mortality. Oral symptoms in systemic lupus erythematosus sle patients are often unexplored and affect the healthrelated quality of life. It typically presents as an area of welldemarcated erythema or erosion with central white papules surrounded by white radiating striae. Oral manifestations include swollen lips, often with extensive crust formation, and gingival lesions that involve bullae that rupture and leave ulcers. Oral lesions of lupus erythematosus show an array of clinical aspects and most affected sites are lips and buccal mucosa 1, 2. Systemic lupus erythematosus sle is a serious multisystem disease with variety of cutaneous and oral manifestations. This article highlights methods torecognize and manage the oral manifestations of this systemic disease. Learn more about lupus triggers and how to control your symptoms on the managing lupus page. Stress, exhaustion, smoking or sun exposure can trigger lupus.
Systemic lupus erythematosus sle, or lupus, is an autoimmune disease that causes damage to various organs or cells of the body. Lupus specific skin diseases include chronic cutaneous, subacute cutaneous, and acute cutaneous lupus erythematosus. Systemic lupus erythematosus sle is a multiorgan autoimmune disease of unknown etiology that can have many clinical manifestations table 1. Squamous cell carcinoma arising within oral lupoid plaques. Reseacharicle oral manifestations of systemic lupus erythematosus patients in qatar. Lupus erythematosus is a serious autoimmune disease, which can cause oral mucosal lesions, manifesting as white striae and erythematous, atrophic and hyperkeratotic areas, as well as erosions and ulcerations. In the past, different studies have investigated the occurrence of remissions. Systemic lupus erythematosus sle can involve many parts of the eye, including the eyelid, ocular adnexa, sclera, cornea, uvea, retina and optic nerve. Neonatal lupus, which can occur in babies of women with sle expressing antirossa and antilassb, can cause heart block of varying degrees that may be noted in utero andor that may present as. Its effect on oral health is the development of symptoms such as acute sudden onset with short period of duration or chronic lingers for a very long period of time soft tissue lesions. Study procedures took place between november 2014 and april 2016. Cutaneous lupus, which causes a rash or lesion on the skin, usually when exposed to sunlight. Lupus is a chronic autoimmune condition that causes inflammation throughout your body. Other symptoms can include sun sensitivity, oral ulcers, arthritis, lung problems, heart problems, kidney problems, seizures, psychosis, and blood cell and immunological abnormalities.
Systemic lupus erythematosus sle, is the most common type of lupus. Lupus symptoms also usually come and go, meaning that you dont have them all of the time. Oct 17, 2018 lupus is a chronic, autoimmune disease that can damage any part of the body. Lesions may be part of systemic lupus or may represent discoid lupus without organ involvement, which is a separate diagnostic entity. Oral manifestations of lupus journal of the american. Ocular manifestations of sle are common and may lead to permanent blindness from the underlying disease or therapeutic side effects. Lupus systemic lupus erythematosus emedicinehealth. It is an autoimmune disease where bodys immune system antibodies in this case referred to as autoantibodies mistakenly attacks its own tissues, causing multiorgan inflammation and diverse clinical manifestations with domination of peripheral symmetric polyarthritis of small and. Both discoid lupus erythematosus and systemic lupus are more common in women than men about eight times more common. It is a multisystem disease, and patients can present in vastly different ways. Objective the purpose of this pilot study was to assess the prevalence of oral manifestations among systemic lupus erythematosus sle patients in qatar, in order to warrant future studies that. Systemic lupus erythematosus sle is a chronic autoimmune disease that can involve any organ system with a wide range of disease manifestations, and. Lupus is a disease of flares the symptoms worsen and you feel ill and remissions the symptoms improve and you feel better.
Systemic lupus erythematosus is a multisystem autoimmune disease characterized by general autoantibody production and a wide range of mucocutaneous, renal, neuropsychiatric, cardiovascular, infectious, and hematologic manifestations. According to the 1982 revised criteria for systemic lupus erythematosus, a diagnosis of sle can be made by the serial or simultaneous presentation of at least 4 of the following 11 criteria. Systemic lupus erythematosus, the most common form of the condition, can potentially. Information for behavioral health providers in primary care. Pulmonary manifestations of systemic lupus erythematosus abdul ghafoor gari, amr telmesani and raad alwithenani umm alqura university saudi arabia 1. It is an auto immune disease, where the patient develops auto antibodies to many of their cells and cell components and tissues. Half of the patients had positive oral findings, 26% had no oral examination documented, and 24% had documented normal oral examinations. A number of medications are associated with cutaneous. Discoid lupus erythematosus dle, a chronic dermatological disease, is the most common form of chronic cle. A pilot study mohammedhammoudeh,1 ahmedalmomani,2 husamsarakbi,1 premchandra,3 andsamerhammoudeh 4 departmentofmedicine,hamadmedicalcoporaion,p. The diagnosis and treatment of systemic lupus erythematosus.
Lupus is more common among women of childbearing age ages 15 to 44 years. Systemic lupus erythematosus sle is a disease that can affect persons of all ages and ethnic groups and both sexes, but more than 90% of new patients presenting with sle are women in the childbearing years. A study conducted in venezuela on 90 systemic and cutaneous lupus erythematosus patients reported that 11% had oral lesions including oral ulcerations, erythema, and white plaque. Cutaneous manifestations of systemic lupus erythematosus a retrospective study k uma maheswari1, b vijayalakshmi1, m vasantha kumar2, e k jaleena3, heber anandan4 1assistant professor, department of dermatology, madras medical college and rajiv gandhi government general hospital, chennai.
Jul 17, 2016 lupus erythematosus lupus erythematosus le may be seen in one of two wellrecognized forms systemic acute lupus erythematosus sle profound impact it has on many organs discoid chronic lupus erythematosus dle chronic and localised skin lesions involving the bridge of nose and adjacent cheeks without any. Classically, it involves the hard palate helping to differentiate it from oral lichen planus. Clinical manifestations of cutaneous lupus erythematosus. Oral findings in lupus are common but understudied relative to other manifestations of disease. While this fact sheet focuses on sle, and not on discoidcutaneous lupus skin and mucosa only nor druginduced lupus temporary, a few italicized comments are made regarding the latter two forms of lupus. Causes of lupus or systemic lupus erythematosus sle. Pdf cutaneous manifestations of systemic lupus erythematosus. Ocular manifestations in systemic lupus erythematosus. Impact of systemic lupus erythematosus on oral health. Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder. Systemic lupus erythematosus lupus is latin for wolf, erythro in greek stands for red, and systemic is english word meaning that multiple organs are involved. Oral ulcers are a criterion in the main classification systems with prevalence estimates varying widely from 7% to 54%, in part due to varying rigor in examining the oral mucosa, the asymptomatic nature of some lesions, and reporting biases. Oral ulceration may be found in patients with lupus erythematosus, pemphi gus vulgaris, or crohn disease.
Oral manifestations of systemic and cutaneous lupus erythematosus in a venezuelan population article in journal of oral pathology and medicine 369. Pulmonary manifestations of systemic lupus erythematosus. Valvular heart disease as a cause of cerebrovascular disease in patients with systemic lupus erythematosus. Oral biopsies were taken from patients who showed oral mucosal involvement. Mar 18, 2020 systemic lupus erythematosus sle is a chronic autoimmune disease that can affect almost any organ system.
Eleven patients had oral discoid lesions without involvement of the skin. This means that your immune system starts to attack your body instead of harmful germs. Lesions are discshaped, erythematous plaques of varying size. Cutaneous manifestations of systemic lupus erythematosus. Lupus erythematosus le is a chronic, autoimmune, multisystem disease that displays many diverse symptoms in which localized cutaneous le cle is on one end of the spectrum and severe systemic le sle on the other end. Ocular manifestations of systemic lupus erythematosus. A study conducted in saudi arabia on 46 sle patients reported mucocutaneous involvement including oral ulcers in 72% and discoid lupus in % of the sample 18. We analysed the prevalence of clinical manifestations and immunological parameters in 194 patients with sle and classified them in subgroups according to age at onset, gender and type of antibodies. Lupus nephritis report of a case article pdf available in general dentistry 561.
Systemic lupus erythematosus is chronic inflammatory multisystem disease of unknown etiology. Systemic lupus erythematosusoral manifestations and. Oral manifestations of lupus erythematosus sciencedirect. Noting that many people with lupus had a disease that not only affected the skin but many other organs in the body as well, osler added the word systemic to the term lupus erythematosus to distinguish this type of disease from discoid lupus erythematosus. Introduction systemic lupus erythematosus sle is an auto immune disease that primarily affects women of childbearing age with 10. The clinical course is variable, with a broad spectrum of organ manifestations. Systemic lupus erythematosus sle is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. Sometimes, these signs can be misdiagnosed as other oral diseases such as lichen planus.
Oral manifestation of systemic lupus erythematosus. Oral manifestations of systemic and cutaneous lupus erythematosus in a venezuelan population. Lupus erythematosus le is a multifactorial autoimmune disease, which may affect the oral mucosa in either its cutaneous and systemic forms, with varied prevalence. Central nervous system manifestations of systemic lupus erythematosus cns lupus describe a wide variety of neuropsychiatric manifestations that are secondary to systemic lupus erythematosus sle in the central nervous system cns. Its presentation and course are highly variable, ranging from indolent to fulminant. This can be obtained thanks to specific knowledge of oral manifestations of autoimmune diseases. Mar 18, 2020 lupus, a chronic autoimmune disorder that causes inflammation, creates a wide range of signs and symptoms.
Lupus is a lifelong disease that affects all parts of your body. In numerous investigations, it has been shown that exogenous factors, such as. Review pathogenesis of systemic lupus erythematosus. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Pdf oral manifestation of systemic lupus erythematosus. The time of onset of the oral discoid lesions rnaged from 6 to 75 years with a mean of 41 years. Chronic means that the signs and symptoms tend to last longer than six weeks and often for many years.
The skin is one of the target organs most variably affected by the disease. A combination of traditional and nontraditional risk factors, including dyslipidemia and to a varying degree, hypertension, diabetes, and smoking, inflammation, antiphospholipid antibodies apls, and lipid oxidation, contribute. This case report presents a clinical profile of a patient with sle along with different oral lesions. Clinical manifestations lupus erythematosus arthritis. Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat. Oral manifestations of patients with lupus erythematosus. One theory explains that this disease has gotten its name because it is similar to. Lupus is a complex and poorly understood condition that affects many parts of the body and causes symptoms ranging from mild to lifethreatening. Hence, in the present study we present a case of a 70yearold female suffering from sle with oral manifestations. Lupus is a chronic, autoimmune disease that can damage any part of the body skin, joints, andor organs inside the body. Daily selfcare and 2 to 3month maintenance care should be considered to control andor prevent sle oral manifestations.
Systemic lupus erythematosus lupus is a chronic longlasting autoimmune disease that can affect many parts of the body. Mucosal involvement is commonly seen in patients with lupus. Systemic lupus erythematosus sle clinical presentation. Tissue samples were investigated with histology and direct immunofluorescence techniques for the presence of.
Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli. Systemic lupus erythematosusoral manifestations and adverse. It can affect all organs and systems and affects nearly 1 in in the uk. Autoimmune disease, lupus erythematosus, periodontal disease introduction systemic lupus erythematosus sle is a systemic, chronic inflammatory condition with. Sle is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. Although the exact etiology of systemic lupus erythematosus sle remains obscure, it is clear that many of the clinical manifestations of sle are mediated directly severe than in adults, with a high incidence of malar rashes, nephritis, pericarditis, hepatosplenomegaly, and hematologic abnormalities. The aim of this study was to characterize oral lesions in patients with systemic and cutaneous lupus erythematosus le in a venezuelan group. Among the oral manifestations is periodontal disease pd, which is an infection of the tissue. In sle that initiated before the age of 20 years, the most frequent manifestation at onset was malar rash 25% vs 14%. Systemic lupus erythematosus sle still has the reputation of a fatal condition, with no cure, although it is the main goal of treatment to achieve remission. The skin is involved in up to 85% of systemic lupus erythematosus sle cases and may be the only organ involved in cutaneous lupus erythematosus cle. Cutaneous manifestations of systemic lupus erythematosus a. The prevalence of oral manifestations of systemic lupus.
Autoimmune diseases and their manifestations on oral. Our findings suggest that oral pathology is common in this. Lupus, technically known as systemic lupus erythematosus sle, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. Oral manifestations of systemic and cutaneous lupus. Squamous cell carcinoma arising within oral lupoid plaques has been described, emphasizing the importance of identifying and treating oral lupus. You may experience pain and stiffness, with or without swelling. Oral ulcers are classified as lupus erythematosus le specific, where the lesional biopsy shows a unique pattern of mucosal change in le, and le nonspecific, where the ulcers and their. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain.
Lupus is an autoimmune condition caused by a combination of factors, both genetic and environmental. Lupus can affect almost any organ in your body, which can lead to a variety of different symptoms. See noncoronary cardiac manifestations of systemic lupus erythematosus in adults and coronary heart disease in systemic lupus erythematosus. The clinical management of systemic lupus erythematosus, 2nd, schur ph ed, lippincott, philadelphia 1996. So if you have these common lupus symptoms, its important to talk to your doctor and find out whether you have lupus or a different health problem. A wide spectrum of clinical manifestations, however, ranging from cellulitis and soft tissue abscesses to pyomyositis are seen in these patients. Prevalence varies with ethnicity, but is estimated to be about 1 per overall with a female to male ratio of 10. Discoid lupus affects only the skin and does not usually involve internal organs. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated. Systemic lupus erythematosus sle is a prototypic autoimmune disease characterised by the production of antibodies to components of the cell nucleus in association with a diverse array of clinical manifestations.1192 542 978 335 546 1474 558 1046 1034 77 33 98 1533 1059 1003 1204 1487 582 1118 147 989 439 657 1285 1441 1123 96 660 715 491 1301 1014